Hypokalemic PP

Periodic Paralysis and the New Mother

Anticipating the Baby


Expectant mothers and their doctors can take the secure thought that hundreds of women with periodic paralysis have been members of our Listserv since 1995, and an overwhelming majority of them have been mothers. To date not a single one has been unable to care for her child due to her periodic paralysis.

Meet Our Patients

Irm's Story

The PPI's Client Services Representative in The Netherlands is Irm. Irm and her son were clinically diagnosed with HypoKPP-plus in Germany in September 2011, but she has had symptoms since she was a young child. At the age of 7, she told her parents, “My head is awake but my body still sleeps”. 

Physician's Reading Room

For your convenience, arranged by topic, a "shelf" of journal articles on the periodic paralyses.

If you have a favorite link to suggest please pass it along.

Nondystrophic Myotonias and Periodic Paralyses

This chapter from McGraw Hill's Myology, third edition; editors Andrew Engel and Clara Franzini-Armstrong,  give a comprehensive look at the nondystrophic myotonias and periodic paralyses, written by one of the world's top teams in the field.

Chapter from Myology, third edition: Nondystrophic Myotonias and Periodic Paralyses by Frank Lehmann-Horn, Reinhardt Rudel and Karin Jurkat-Rott.

Our thanks to Professor Dr. Lehmann-Horn, Dr. Jurkat-Rott and Dr. Rudel for your kind permission to include this valuable information on our website!

How is periodic paralysis diagnosed?

Do you suspect that you might have periodic paralysis? The periodic paralyses are a rare group of disorders and there are many conditions which cause an imbalance in serum potassium. So how does the doctor tell the difference between paralysis or weakness caused by an ion channelopathy and any of the other numerous disorders, conditions and reactions which might produce the same symptoms?

Management Strategies For Hypokalemic Periodic Paralysis

In 2009 Professor Dr. Frank Lehmann-Horn of Ulm University, Ulm Germany, gave a presentation on managing hypokalemic periodic paralysis at the Periodic Paralysis Association's conference held in Orlando Florida. This presentation contained so much valuable information in such a compact and understandable format that we asked Dr. Lehmann-Horn for his permission to include it on our website, for the benefit of physicians and patients.

Anesthesia in Hypokalemic Periodic Paralysis

Provided by Frank Lehmann-Horn MD, PhD

Lehmann-Horn F, Rüdel R, Jurkat-Rott K. Chapter 46: Nondystrophic myotonias and periodic paralyses. In: Myology, edited by AG Engel, C Franzini-Armstrong. McGraw-Hill, New York, 3rd edition, 2004, pp. 1257-1300.
Klingler W, Lehmann-Horn, Jurkat-Rott K. Complications of anesthesia in neuromuscular disorders. Neuromuscular Disord, 15:195-206, 2005.

Pursuing a Diagnosis of Periodic Paralysis:

A free workbook to download for those who are in the diagnostic process, contains information on each type of PP, diagnostic testing, available therapies, how to determine episode triggers and  work out a management plan. download here

Diagnostic Flowchart for Diagnosing Hypokalemic Periodic Paralysis

The normal renal response when hypokalemia is due to non-renal causes is a TTKG <2, where a TTKG >5 is indicative of increased secretion of K+ in the cortical collecting ducts. Thus a transtubular potassium concentration gradient (TTKG) of greater than 3.0 indicates hypokalemia of renal origin, while a value below 2.0 indicates intracellular shift of K+, as found in ion channelopathy hypokalemic periodic paralysis.

Role of Potassium in Maintaining Health

by Elson M. Haas, M.D.


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