Medications

FDA Approves Taro’s Keveyis™ (dichlorphenamide) for Primary Periodic Paralysis

FDA Approves Taro’s Keveyis™ (dichlorphenamide) for Primary Hyperkalemic and Hypokalemic Periodic Paralysis

Orphan Drug is First Approved Treatment for Patients Living with Rare Debilitating Disease
 

Keveyis is now supplied free of charge to US patients by Taro Pharmaceuticals. The process is handled by Envoy Health.

The numbers for Envoy are: 1-855-768-9727 and 1-810-553-4090.

You need a prescription from your doctor, but call Envoy first for instructions on how to apply and proceed.

Converting Mg of Potassium to MeQ or MmoL

 

Source: Levitt, Jacob O, Practical aspects in the management of hypokalemic periodic paralysis. Journal of Translational Medicine 2008, 6:18 doi:10.1186/1479-5876-6-18:

The Use of Bactrim in the Periodic Paralyses

The antibiotic Bactrim is well-known to produce muscle weakness, even paralysis in patients with Hypokalemic Periodic Paralysis.

Starting Acetazolamide (Diamox)

Because this is a frequently asked question from patients we post here a reply:

Question:

My doctor wants to prescribe a medication called acetazolamide. Is that okay for someone with Hypokalemic periodic paralysis. When I look on the web it says this medication causes you to excrete potassium. How can that be good for me?

Answer:

New Findings Suggest Genetics Behind Drug Response

PLoS One. 2012; 7(7): e40235.
Published online 2012 July 10.

Splicing of the rSlo Gene Affects the Molecular Composition and Drug Response of Ca2+-Activated K+ Channels in Skeletal Muscle

Maria Maddalena Dinardo,#1 Giulia Camerino,#1 Antonietta Mele,1 Ramon Latorre,2 Diana Conte Camerino,1 and Domenico Tricarico1,*

Abstract

Physician's Sheet: Acetazolamide Drug Interactions

Acetazolamide (aka Diamox) is frequently prescribed as therapy for the periodic paralyses. While most patients take this drug without incident it can interact with other drugs. Physicians should be aware of potential problems which might arise.

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