Physician’s Summary Hypokalemic periodic paralysis (HypoKPP) is one of the primary forms of periodic paralysis, caused by one or more mutations in the calcium, sodium or potassium ion channels in muscle membrane. Features of Hypokalemic Periodic Paralysis There are two forms of HypoKPP, a paralytic form and a myopathic form. The paralytic form is more…
What is Hypokalemic Periodic Paralysis? Hypokalemic Periodic Paralysis (HypoKPP) is a rare inherited muscle disorder which is estimated to occur in only one of 100,000 individuals. Because it is inherited there may be several members in a single family who have the disorder, which makes it obvious that the one in 100,000 figure is a…
A Quick Overview of Hypokalemic PP 1) Patient has “attacks” of weakness and/or floppy paralysis which have clearly defined beginnings and endings. 2) First attacks occur by the age of 16 in 65% of patients. 3) Attacks follow triggering events (vigorous exercise, intense short-term stress, fright) or a meal high in carbohydrate and/or sodium (baked…
Submitted by deb on Mon, 06/27/2011 – 23:16 Are Weakness and Fatigue Between Paralytic Attacks Symptoms of Periodic Paralysis? Patients frequently report that their physician denies that muscle weakness and fatigue between paralytic attacks are a part of periodic paralysis. While it was reported in the past that patients with periodic paralysis had ‘normal’ muscle strength and…
Submitted by deb on Thu, 06/21/2012 – 16:31 1) Patient has “attacks” of weakness and/or floppy paralysis. 2) First attacks occur by the age of 16 in 65% of patients. 3) Attacks follow triggering events (vigorous exercise, intense stress, fright) or a meal high in carbohydrate and/or sodium (baked goods, pizza, Chinese food, sugar-sweetened soda, beer, etc.)….
Submitted by deb on Mon, 09/18/2017 – 22:19 Hypokalemic periodic paralysis (HypoKPP) is one of the primary forms of periodic paralysis, caused by one or more mutations in the calcium, sodium or potassium ion channels in muscle membrane. Features of Hypokalemic Periodic Paralysis There are two forms of HypoKPP, a paralytic form and a myopathic form. The paralytic…
Submitted by ian on Tue, 06/21/2011 – 22:55 The periodic paralyses are a group of rare inherited disorders that cause temporary episodes of muscle weakness or paralysis. Periodic Paralysis is found in all races and in both sexes. Some patients have their first attack within minutes of birth, but a few don’t have symptoms until they are…
Submitted by deb on Tue, 04/12/2016 – 22:54 Adverse reactions to anaesthesia, including life-threatening events, are a serious concern for patients with Periodic Paralysis Disorders. Many of our patients report serious events associated with anesthesia and side effects which may linger for days to months. There is rarely time for a surgical team to comb through journals…
Submitted by deb on Tue, 07/03/2012 – 18:45 Measuring quality of life impairment in skeletal muscle channelopathies. Eur J Neurol. 2012 May 19. doi: 10.1111/j.1468-1331.2012.03751.x. [Epub ahead of print] Sansone VA, Ricci C, Montanari M, Apolone G, Rose M, Meola G; INQoL Group. SourceDepartment of Neurology, University of Milan, IRCCS Policlinico San Donato, Milan, Italy. Abstract Link to…
Submitted by deb on Sat, 07/02/2011 – 18:02 Introduction: The major features found in all the periodic paralyses are: 1. Attacks almost always begin before the age of 25, though occasionally later in life. ATS patients can develop first symptoms at any age. 2. Serum potassium fluctuates shortly before an attack, but serum potassium level will normalize…