*Hypokalemic Periodic Paralysis

Physician’s Summary Hypokalemic periodic paralysis (HypoKPP) is one of the primary forms of periodic paralysis, caused by one or more mutations in the calcium, sodium or potassium ion channels in muscle membrane. Features of Hypokalemic Periodic Paralysis There are two forms of HypoKPP, a paralytic form and a myopathic form. The paralytic form is more…

*Hypokalemic Periodic Paralysis

A Quick Overview of Hypokalemic PP 1) Patient has “attacks” of weakness and/or floppy paralysis which have clearly defined beginnings and endings. 2) First attacks occur by the age of 16 in 65% of patients. 3) Attacks follow triggering events (vigorous exercise, intense short-term stress, fright) or a meal high in carbohydrate and/or sodium (baked…

The Abortive Attack – Weakness Between Attacks

Submitted by deb on Mon, 06/27/2011 – 23:16 Are Weakness and Fatigue Between Paralytic Attacks Symptoms of Periodic Paralysis? Patients frequently report that their physician denies that muscle weakness and fatigue between paralytic attacks are a part of periodic paralysis. While it was reported in the past that patients with periodic paralysis had ‘normal’ muscle strength and…

Hypokalemic Periodic Paralysis

Submitted by deb on Mon, 09/18/2017 – 22:19 Hypokalemic periodic paralysis (HypoKPP) is one of the primary forms of periodic paralysis, caused by one or more mutations in the calcium, sodium or potassium ion channels in muscle membrane. Features of Hypokalemic Periodic Paralysis There are two forms of HypoKPP, a paralytic form and a myopathic form. The paralytic…

What is Periodic Paralysis?

Submitted by ian on Tue, 06/21/2011 – 22:55 The periodic paralyses are a group of rare inherited disorders that cause temporary episodes of muscle weakness or paralysis. Periodic Paralysis is found in all races and in both sexes. Some patients have their first attack within minutes of birth, but a few don’t have symptoms until they are…

Anaesthesia and peri-operative care in the primary Periodic Paralysis Disorders

Submitted by deb on Tue, 04/12/2016 – 22:54 Adverse reactions to anaesthesia, including life-threatening events, are a serious concern for patients with Periodic Paralysis Disorders. Many of our patients report serious events associated with anesthesia and side effects which may linger for days to months. There is rarely time for a surgical team to comb through journals…

Measuring quality of life impairment in periodic paralyses

Submitted by deb on Tue, 07/03/2012 – 18:45 
Measuring quality of life impairment in skeletal muscle channelopathies.
 Eur J Neurol. 2012 May 19. doi: 10.1111/j.1468-1331.2012.03751.x. [Epub ahead of print] Sansone VA, Ricci C, Montanari M, Apolone G, Rose M, Meola G; INQoL Group.
SourceDepartment of Neurology, University of Milan, IRCCS Policlinico San Donato, Milan, Italy.
 Abstract   Link to…