Physician’s Summary Paramyotonia Congenita (PMC) is one of the periodic paralyses caused by mutations in the sodium channel. PMC causes muscle stiffness (myotonia) which is made worse by chilling or activity. Myotonia usually eases when the patients moves about, or “warms up” through physical activity. In PMC myotonia develops during activity, which is paradoxical or…
Paramyotonia congenita (PMC) is a muscle disorder which causes muscle stiffness (myotonia) that appears during exercise and becomes much more severe upon exposure to cold. The myotonia which occurs during attacks of PMC may be so severe that the patient cannot inhale and exhale properly, and movement becomes difficult. The medical term myotonia means that…
Submitted by deb on Sun, 06/26/2011 – 00:05 Paramyotonia Congenita (PMC) is one of the periodic paralyses caused by mutations in the sodium channel. PMC causes muscle stiffness (myotonia) which is made worse by chilling or activity. Myotonia usually eases when the patients moves about, or “warms up” through physical activity. In PMC myotonia develops during activity, which is paradoxical or…
Submitted by deb on Sun, 11/09/2014 – 21:32 Focal and abnormally persistent paralysis associated with congenital paramyotonia. Magot A1, David A2, Sternberg D3, Péréon Y1. British Medical Journal Case Report 2014 Jun 17;2014. Abstract Mutations of the skeletal muscle voltage-gated sodium channel (NaV1.4) are an established cause of several clinically distinct forms of periodic paralysis and myotonia….
Submitted by deb on Mon, 06/27/2011 – 23:16 Are Weakness and Fatigue Between Paralytic Attacks Symptoms of Periodic Paralysis? Patients frequently report that their physician denies that muscle weakness and fatigue between paralytic attacks are a part of periodic paralysis. While it was reported in the past that patients with periodic paralysis had ‘normal’ muscle strength and…
Submitted by ian on Tue, 06/21/2011 – 22:55 The periodic paralyses are a group of rare inherited disorders that cause temporary episodes of muscle weakness or paralysis. Periodic Paralysis is found in all races and in both sexes. Some patients have their first attack within minutes of birth, but a few don’t have symptoms until they are…
Submitted by deb on Tue, 04/12/2016 – 22:54 Adverse reactions to anaesthesia, including life-threatening events, are a serious concern for patients with Periodic Paralysis Disorders. Many of our patients report serious events associated with anesthesia and side effects which may linger for days to months. There is rarely time for a surgical team to comb through journals…
Submitted by deb on Tue, 07/03/2012 – 18:45 Measuring quality of life impairment in skeletal muscle channelopathies. Eur J Neurol. 2012 May 19. doi: 10.1111/j.1468-1331.2012.03751.x. [Epub ahead of print] Sansone VA, Ricci C, Montanari M, Apolone G, Rose M, Meola G; INQoL Group. SourceDepartment of Neurology, University of Milan, IRCCS Policlinico San Donato, Milan, Italy. Abstract Link to…
Submitted by deb on Sat, 07/02/2011 – 18:02 Introduction: The major features found in all the periodic paralyses are: 1. Attacks almost always begin before the age of 25, though occasionally later in life. ATS patients can develop first symptoms at any age. 2. Serum potassium fluctuates shortly before an attack, but serum potassium level will normalize…
Annabelle SJ Baughan [1] MB FRCP FRCPath,Deborah Cavel-Greant [1],Janice Megalo [1] AAS-MAA, andFrank Weber [2] MD PhD.[1] Periodic Paralysis International (www.hkpp.org)[2] Colonel, Medical Service (Neurology), German Air Force. Military Hospital (Bundeswehrkrankenhaus), 89081 Ulm, & German Air Force Center of Aerospace Medicine, D-82256 Fürstenfelbruck. Medical Adviser, Periodic Paralysis Association;Corresponding author: ASJ Baughan@gmail.com With grateful acknowledgement to…