Pain in the Periodic Paralyses

Submitted by deb on Sat, 06/25/2011 – 23:22 Pain Often Overlooked Pain is an often overlooked component of the periodic paralyses. Patients who report muscle pain in association with their episodes are too often told that the periodic paralyses are not painful despite many authoritative reports to the contrary. In fact the pain which accompanies the periodic…

The Use of Bactrim in the Periodic Paralyses

Submitted by deb on Sat, 07/25/2015 – 18:54 The antibiotic Bactrim is well-known to produce muscle weakness, even paralysis in patients with Hypokalemic Periodic Paralysis. It is contraindicated in patients with Anderson-Tawil Syndrome because of its propensity to produce cardiac arrhythmia, but many clinicians do not realize that it also produces hyperkalemia in a majority of patients…

Sleep Complaints in Periodic Paralysis

Submitted by deb on Mon, 06/27/2011 – 02:57 Giorgio Buzzi, MD, Neurologist Buzzi G, Mostacci B, Sancisi E, Cirignotta F. Sleep complaints in Periodic Paralyses: a web survey. Functional Neurology 2001, 17 (3). From the Sleep Medicine Unit – Dept. of Neurology S.Orsola-Malpighi Hospital – University of Bologna, Italy. SUMMARY Section 1. Background: K+ and REM sleep homeostasis….

Physician’s Reading Room

Submitted by deb on Wed, 09/07/2011 – 03:04 For your convenience, arranged by topic, a “shelf” of journal articles on the periodic paralyses. If you have a favorite link to suggest please pass it along. Textbook and Reviews Meola G, Hanna M G and Fontaine B. Diagnosis and Treatment of Muscle Channelopathies. J Neurol Neurosurg Psychiatry 2009;80:360–365. Dr Michael…

New Findings Suggest Genetics Behind Drug Response

Submitted by deb on Thu, 07/26/2012 – 17:00 PLoS One. 2012; 7(7): e40235.Published online 2012 July 10. Splicing of the rSlo Gene Affects the Molecular Composition and Drug Response of Ca2+-Activated K+ Channels in Skeletal Muscle Maria Maddalena Dinardo,#1 Giulia Camerino,#1 Antonietta Mele,1 Ramon Latorre,2 Diana Conte Camerino,1 and Domenico Tricarico1,* The molecular composition and drug responses…

Leaky Channels make weak muscles

Submitted by deb on Wed, 03/13/2013 – 18:08 Leaky channels make weak muscles: Mutations in the skeletal muscle voltage-gated calcium channel (CaV 1.1) have been associated with hypokalemic periodic paralysis, but how these mutations cause the symptoms of the disorder has always been unclear. In this article the authors describe how they used mice with the CaV 1.1…

Malignant Hyperthermia

Submitted by deb on Mon, 06/27/2011 – 19:16 Periodic Paralysis Patients at Increased Risk of MH Patients with Hyperkalemic periodic paralysis and Paramyotonia Congenita are at increased risk for Malignant Hyperthermia (MH) during surgery.  Patients with all types of periodic paralysis often become paralyzed during or after surgery, from stress, chilling in the OR and the use…