Hyperkalemic PP Medications

A True Endocrine Emergency Carbonic Anhydrase InhibitorsDichlorphenamide is an FDA approved carbonic anhydrase inhibitor used for primary hypo and hyperforms of periodic paralysis. The exact mechanism of action for these conditions is unknown. It isavailable as the brand name Keveyis from Xeris pharmaceutical. It has also recently been made availablein a generic form. For the…

*Hyperkalemic Periodic Paralysis FAQ

Patients with Hyperkalemic PP (HyperKPP) develop paralysis or weakness (and sometimes muscle stiffness) when they eat potassium-rich food. This is also referred to as ‘potassium sensitive’ periodic paralysis. This is usually called Hyperkalemic Periodic Paralysis because most patients’ potassium levels rise during attacks. HyperKPP is due to a mutation in the sodium channel.  Hyperkalemic Periodic…

*Emergency Care HyperKPP & PMC

Emergency Treatment of the HyperKalemic Periodic Paralysis and/or Paramyotonia Congenita Attack First Actions: Hyperkalemic Periodic Paralysis and Paramyotonia Congenita can occur singly or in combination.  While most attacks of Hyperkalemic Periodic Paralysis are brief and do not require emergency intervention, occasionally the serum potassium level will be high enough to cause cardiac distress, or muscle stiffness may…

Links out – Diagnosis and Management Information

Submitted by deb on Wed, 07/20/2011 – 19:51 Communication is key: Stephen Wilkins, MPH, writes of improving practice management through improved patient/physician communication and its impact on care, in Mind the Gap. Practical aspects in the management of hypokalemic periodic paralysis.   Author: Jacob O Levitt MD; Management considerations in hypokalemic periodic paralysis include accurate diagnosis, potassium dosage for acute attacks,…

Long-time exercise test in the diagnosis of periodic paralysis

Submitted by deb on Fri, 01/16/2015 – 00:37 Ding Z, Liu M, Cui L. Reference value of long-time exercise test in the diagnosis of primary periodic paralysis. Chin Med J (Engl). 2014;127(18):3219-23. Abstract BACKGROUND:The long-time exercise test (ET) is used to diagnose the primary periodic paralyses (PPs). However the reference values of ET are many and various….

Dichlorphenamide: A Review in Primary Periodic Paralyses.

Submitted by deb on Sun, 11/09/2014 – 21:46 Dichlorphenamide: A Review in Primary Periodic Paralyses. Greig SL; Drugs. 2016 Mar;76(4):501-7. doi: 10.1007/s40265-016-0559-2. Abstract Oral dichlorphenamide (Keveyis™) is a carbonic anhydrase inhibitor that is approved in the USA for the treatment of primary hyperkalaemic and hypokalaemic periodic paralyses and related variants. The efficacy and safety of dichlorphenamide in…

Malignant Hyperthermia and HyperKPP/PMC

Submitted by deb on Mon, 06/27/2011 – 20:16 Patients with Sodium channel HyperKPP and PMC mutations are at increased risk of Malignant Hyperthermia; It has long been recognized that patients with hyperkalemic periodic paralysis are at increased risk for Malignant Hyperthermia (MH) during surgery, showing as fulminant muscle rigidity as seen in the jaw muscles, rhabdomyolysis, hypercarbia, and…