Submitted by deb on Sun, 11/09/2014 – 21:46 Dichlorphenamide: A Review in Primary Periodic Paralyses. Greig SL; Drugs. 2016 Mar;76(4):501-7. doi: 10.1007/s40265-016-0559-2. Abstract Oral dichlorphenamide (Keveyis™) is a carbonic anhydrase inhibitor that is approved in the USA for the treatment of primary hyperkalaemic and hypokalaemic periodic paralyses and related variants. The efficacy and safety of dichlorphenamide in…
Submitted by deb on Mon, 05/19/2014 – 21:54 GUIDELINES ved indlæggelse for Hypokalemisk Periodika Paralyse Patient Navn & CPRnrHøjde: cmVægt: kgAdresse:Egen læge:Emergency contact: navn (tlf: )+ evt personlige assistent og/eller ledsager: OPMÆRKSOMHED: patienten placeres i aflåst sideleje for at holde luftveje frie/åbne ved anfald. De paralytiske anfald kan hurtigt udvikle sig til lammelse og respirationssvigt.– overvåg patienten nøje….
Submitted by deb on Sat, 06/25/2011 – 20:31 First Actions: Paralytic attacks of Hypokalemic Periodic Paralysis can cause cardiac and/or respiratory distress or arrest. Patients may become unable to cough and may choke on their own secretions or on vomit. Attacks of profound paralysis or ones in which there is cardiac or respiratory distress require immediate emergency…
Submitted by deb on Mon, 06/27/2011 – 04:39 The regular colonoscopy prep can cause a hypokalemic episode in a patient with hypokalemic periodic paralysis. This colonoscopy prep, adapted to avoid hypokalemia, has been used by numerous patients with HypoKPP on the HKPP Listserv without provoking an episode afterwards. Colonoscopy Prep: Day 1 Normal diet with an herbal tea…
Submitted by deb on Fri, 03/01/2013 – 17:49 Severe respiratory phenotype caused by a de novo Arg528Gly mutation in the CACNA1S gene in a patient with hypokalemic periodic paralysis. Authors Kil TH, et al. Journal: Eur J Paediatr Neurol. 2010 May;14(3):278-81. doi: 10.1016/j.ejpn.2009.08.004. Epub 2009 Oct 12. Affiliation: Department of Pediatrics, College of Medicine, Konyang University, 685…
Submitted by deb on Mon, 05/19/2014 – 21:40 Akut behandling af et hypokalemisk paralytisk anfald Første skridt:1. Åndedræts- eller hjerteanfald er mulige2. Tjek hjerte og vejrtrækning – dilatation i hjertet kan forårsage høj puls og lavt blodtryk.3. Foretag måling af hjerterytme/EKG.4. Mål elektrolytter for at bestemme serum K+5. Giv ilt – blodprøve fra fingeren afspejler måske ikke…
Submitted by deb on Wed, 07/27/2011 – 02:17 The normal renal response when hypokalemia is due to non-renal causes is a TTKG <2, where a TTKG >5 is indicative of increased secretion of K+ in the cortical collecting ducts. Thus a trans tubular potassium concentration gradient (TTKG) of greater than 3.0 indicates hypokalemia of renal origin, while…
Submitted by deb on Mon, 06/27/2011 – 23:16 Are Weakness and Fatigue Between Paralytic Attacks Symptoms of Periodic Paralysis? Patients frequently report that their physician denies that muscle weakness and fatigue between paralytic attacks are a part of periodic paralysis. While it was reported in the past that patients with periodic paralysis had ‘normal’ muscle strength and…
Submitted by deb on Thu, 06/21/2012 – 16:31 1) Patient has “attacks” of weakness and/or floppy paralysis. 2) First attacks occur by the age of 16 in 65% of patients. 3) Attacks follow triggering events (vigorous exercise, intense stress, fright) or a meal high in carbohydrate and/or sodium (baked goods, pizza, Chinese food, sugar-sweetened soda, beer, etc.)….
Submitted by deb on Mon, 09/18/2017 – 22:19 Hypokalemic periodic paralysis (HypoKPP) is one of the primary forms of periodic paralysis, caused by one or more mutations in the calcium, sodium or potassium ion channels in muscle membrane. Features of Hypokalemic Periodic Paralysis There are two forms of HypoKPP, a paralytic form and a myopathic form. The paralytic…