Submitted by deb on Wed, 09/07/2011 – 03:04 For your convenience, arranged by topic, a “shelf” of journal articles on the periodic paralyses. If you have a favorite link to suggest please pass it along. Textbook and Reviews Meola G, Hanna M G and Fontaine B. Diagnosis and Treatment of Muscle Channelopathies. J Neurol Neurosurg Psychiatry 2009;80:360–365. Dr Michael…
Submitted by deb on Thu, 07/26/2012 – 17:00 PLoS One. 2012; 7(7): e40235.Published online 2012 July 10. Splicing of the rSlo Gene Affects the Molecular Composition and Drug Response of Ca2+-Activated K+ Channels in Skeletal Muscle Maria Maddalena Dinardo,#1 Giulia Camerino,#1 Antonietta Mele,1 Ramon Latorre,2 Diana Conte Camerino,1 and Domenico Tricarico1,* The molecular composition and drug responses…
Submitted by deb on Wed, 03/13/2013 – 18:08 Leaky channels make weak muscles: Mutations in the skeletal muscle voltage-gated calcium channel (CaV 1.1) have been associated with hypokalemic periodic paralysis, but how these mutations cause the symptoms of the disorder has always been unclear. In this article the authors describe how they used mice with the CaV 1.1…
Submitted by deb on Mon, 06/27/2011 – 02:22 Hao Cheng, MD The use of local anaesthetics on patients with periodic paralysis presents some unusual challenges. Many patients report that these agents trigger weakness or paralysis, a phenomenon which is substantiated in medical literature. Some patients also report that the agents do not produce the desired anaesthesia. The…
Submitted by deb on Mon, 06/27/2011 – 19:16 Periodic Paralysis Patients at Increased Risk of MH Patients with Hyperkalemic periodic paralysis and Paramyotonia Congenita are at increased risk for Malignant Hyperthermia (MH) during surgery. Patients with all types of periodic paralysis often become paralyzed during or after surgery, from stress, chilling in the OR and the use…
Submitted by deb on Fri, 07/01/2011 – 22:01 When evaluating patients for periodic paralysis it is vital to obtain accurate results from blood draws. Because potassium levels which vary only a fraction of a point may be enough to trigger weakness in some patients, the lab may need to be made aware of specialized procedures which should…
Submitted by deb on Sat, 07/02/2011 – 20:58 This chart allows comparison of the forms of primary periodic paralysis, symptoms, clinical and cardiac signs, effect of potassium, triggers and therapies. Form Effect of K+ Age at onset Triggers Relieves Attack Length Myotonia? Hypertrophy Weakness between attacks EKG during attacks Therapies Thyrotoxic HypoKalemic Periodic Paralysis Relieves weakness At…
Do you suspect that you might have periodic paralysis? The periodic paralyses are a rare group of disorders and there are many conditions which cause an imbalance in serum potassium. So how does the doctor tell the difference between paralysis or weakness caused by an ion channelopathy and any of the other numerous disorders, conditions…
Submitted by deb on Sat, 11/19/2011 – 04:20 Anticipating the Baby Expectant mothers and their doctors can take the secure thought that hundreds of women with periodic paralysis have been members of our Listserv since 1995, and an overwhelming majority of them have been mothers. To date not a single one has been unable to care for her…
Submitted by ian on Tue, 06/21/2011 – 22:55 The periodic paralyses are a group of rare inherited disorders that cause temporary episodes of muscle weakness or paralysis. Periodic Paralysis is found in all races and in both sexes. Some patients have their first attack within minutes of birth, but a few don’t have symptoms until they are…